She appeared on a few mid-80s television shows, including Growing Pains and the short-lived Fast Times, as well as made-for-television movies including The Thanksgiving Promise and Infidelity before landing a regular role in the sitcom that lasted only a few episodes Day by Day featuring Douglas Sheehan, Linda Kelsey and Julia Louis-Dreyfus. From 1992 to 1997 her first TV role on the big screen was in the role of Alison Parker in Melrose Place. In 1995, she appeared in a television movie that was made to be made Beauty's Revenge which was also marketed in CD and DVD form under the name "Midwest Obsession". Following this, she went on to portray Georgia Thomas on Ally McBeal from 1997 until 2000. Thorne-Smith initially auditioned for the role of Georgia Thomas in the show, but it ultimately went to Calista Flockhart. Her character was written by Ally McBeal at the beginning of season four in the year 2000 however she did return for brief guest appearances later on. Later, she stated that she quit the show partly due to the pressure to lose weight. US Weekly reported that she began to eat too much, exercise too much, and had weakened her immune system. "The amount of my time consumed by food and being angry over my body was insane. "From 2001 to 2009 she was a character on the show Cheryl on the show According to Jim. In 2007, her real-life pregnancy was not revealed on the show initially however, it was later written into the plot. She signed up to play Alan Harper's love interest Lyndsey McElroy on season seven of, Two and a Half Men, on February 18, 2010. She appeared in 52 episodes from season seven through twelve.
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